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位置: 首页 > 重组兔单抗 > ERCC1 Rabbit mAb

ERCC1 Rabbit mAb#49432

评价
Recombinant
ERCC1 Rabbit mAb
ERCC1 Rabbit mAb
ERCC1 Rabbit mAb
ERCC1 Rabbit mAb
ERCC1 Rabbit mAb
ERCC1 Rabbit mAb
ERCC1 Rabbit mAb
是否有货: Yes
产品总价:
产品详情

产品名称ERCC1 Rabbit mAb

来源种属Recombinant Rabbit

克隆性 Monoclonal antibody

克隆号JM10-07

纯化ProA affinity purified

应用WB, ICC/IF, IHC

种属反应性Hu, Ms

免疫原描述recombinant protein

别名COFS 4 antibody
COFS4 antibody
DNA excision repair protein ERCC 1 antibody
DNA excision repair protein ERCC-1 antibody
DNA excision repair protein ERCC1 antibody
ERCC 1 antibody
ERCC1 antibody
ERCC1_HUMAN antibody
Excision repair cross complementation group 1 antibody
Excision repair cross complementing 1 antibody
Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1 antibody
Excision repair protein antibody
RAD 10 antibody
RAD10 antibody
UV 20 antibody
UV20 antibody

数据库入口号Swiss-Prot#:P07992

计算分子量36 kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情
WB: 1:1,000
IHC: 1:50-1:100
ICC: 1:50

Western blot analysis of ERCC1 on different lysates using anti-ERCC1 antibody at 1/1,000 dilution. Positive control:
Lane 1: Hela
Lane 2: Human lung
Lane 3: 293T
Lane 4: A549
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ERCC1 antibody. Counter stained with hematoxylin.
ICC staining ERCC1 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining ERCC1 in A549 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining ERCC1 in HepG2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining ERCC1 in PANC-1 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining ERCC1 in 293T cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
背景
Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer; it is commonly due to deficiencies in DNA repair enzymes. The most frequent mutations are found in the XP genes from group A through G and group V, which encode for nucleotide excision repair proteins. XPF, which is also designated ERCC4 or ERCC11, associates directly with the excision repair cross-complementing 1 (ERCC1) factor. ERCC-1, a functional homolog of Rad10 in S. cerevisiae, is a component of a structure-specific endonuclease that is responsible for 5' incisions during DNA repair. The ERCC1-XPF endo-nuclease preferentially cleaves one strand of DNA between duplex and single-stranded regions near borders of the stem-loop structure and, thereby, contributes to the initial steps of the nucleotide excision repair process.
背景文献
1. Millis SZ et al. Molecular Profiling of Refractory Adrenocortical Cancers and Predictive Biomarkers to Therapy. Biomark Cancer 7:69-76 (2015).
2. Muallem MZ et al. ERCC1 expression as a predictor of resistance to platinum-based chemotherapy in primary ovarian cancer. Anticancer Res 34:393-9 (2014).

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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