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NOTCH1 Polyclonal Antibody#30991

NOTCH1 Polyclonal Antibody
NOTCH1 Polyclonal Antibody
NOTCH1 Polyclonal Antibody
NOTCH1 Polyclonal Antibody
是否有货: 货期一周
产品总价:
产品详情

产品名称NOTCH1 Polyclonal Antibody

来源种属Rabbit

克隆性Polyclonal

亚型IgG

纯化Affinity purification

应用WB,IHC,IF

种属反应性Hu,Ms,Rt

免疫原描述A synthetic peptide of human NOTCH1

别名NOTCH1; AOS5; AOVD1; TAN1; hN1; notch 1

数据库入口号Swiss-Prot#:P46531
NCBI Gene ID:4851

计算分子量300kDa

配方Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

保存Store at -20˚C

应用详情
WB 1:500 - 1:2000
IHC 1:100 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using NOTCH1 antibody.
Western blot analysis of extracts from normal (control) and NOTCH1 knockout (KO) HeLa cells, using NOTCH1 antibody.
Immunofluorescence analysis of U2OS cells using NOTCH1 antibody.
Immunohistochemistry of paraffin-embedded rat spleen using NOTCH1 antibody.
背景
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.

如果您使用该产品30991发表了文章,请通知我们,让我们可以引用您的文献。

et al,DLX5 promotes osteosarcoma progression via activation of the NOTCH signaling pathway. In Am J Cancer Res on 2021 Jun 15 by Xiaojing Zhang, Huiqin Bian, et al..PMID:34249467, , (2021),
PMID: 34249467
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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