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位置: 首页 > 磷酸化抗体 > CSFR (Phospho-Tyr561) Antibody

CSFR (Phospho-Tyr561) Antibody#11688

CSFR (Phospho-Tyr561) Antibody
CSFR (Phospho-Tyr561) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称CSFR (Phospho-Tyr561) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB IHC

种属反应性Hu

特异性The antibody detects endogenous levels of CSFR only when phosphorylated at tyrosine 561.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of tyrosine 561 (N-S-Y(p)-T-F) derived from Human CSFR .

基因/蛋白名称CSFR

修饰Phospho

别名CD115; CSF-1-R; CSFMR; FMS; M-CSFR

数据库入口号Swiss-Prot#: P07333;
NCBI Gene#: 1436;
NCBI Protein#: NP_001275634.1.

UniprotP07333

实际分子量130kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情

Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100

Western blot analysis of extracts from HepG2 cells treated with PMA using CSFR (Phospho-Tyr561) Antibody #11688.The lane on the right is treated with the antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human brain, using CSFR (Phospho-Tyr561) antibody #11688 (left)or the same antibody preincubated with blocking peptide (right).
背景

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development.

Hampe A., Oncogene Res. 4:9-17(1989).
Andre C., Genomics 39:216-226(1997).
Liu T., J. Proteome Res. 4:2070-2080(2005).

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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