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位置: 首页 > 磷酸化抗体 > TGF β Receptor II (Phospho-Ser225/250) Antibody

TGF β Receptor II (Phospho-Ser225/250) Antibody#11700

TGF β Receptor II (Phospho-Ser225/250) Antibody
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产品总价:
产品详情

产品名称TGF β Receptor II (Phospho-Ser225/250) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用IHC

种属反应性Hu

特异性The antibody detects endogenous levels of TGF β Receptor II only when phosphorylated at serine 225/250.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of Serine 225/250(D-R-S(p)-D-I) derived from Human TGF β Receptor II.

基因/蛋白名称TGF β Receptor II

修饰Phospho

别名 TGF-betaR2; TGFR2; kinase TGF-beta-R2;

数据库入口号Swiss-Prot#: P37173;
NCBI Gene#: 7048;
NCBI Protein#: NP_003233.4.

UniprotP37173

实际分子量64kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情

Immunohistochemistry: 1:50~1:100

Immunohistochemical analysis of paraffin-embedded human brain tissue using TGF β Receptor II (Phospho-Ser225/250) antibody #11700 (left)or the same antibody preincubated with blocking peptide (right).
背景

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.

RC Tripathi, Invest. Ophthalmol. Vis. Sci., Jan 1993; 34: 260.
N Chegini, Endocrinology, Jul 1994; 135: 439.
GW Mulheron, Endocrinology, Dec 1992; 131: 2609

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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