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位置: 首页 > 磷酸化抗体 > IGF1R (Phospho-Tyr1346) Antibody

IGF1R (Phospho-Tyr1346) Antibody#11716

IGF1R (Phospho-Tyr1346) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称IGF1R (Phospho-Tyr1346) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用IHC

种属反应性Hu

特异性The antibody detects endogenous levels of IGF1R only when phosphorylated at tyrosine 1346.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of tyrosine 1346(Q-P-Y(p)-A-H) derived from Human IGF1R .

基因/蛋白名称IGF1R

修饰Phospho

别名CD221; kinase IGF1R; IGF1R;

数据库入口号Swiss-Prot#: P08069;
NCBI Gene#: 3480;
NCBI Protein#: NP_000866.1.

UniprotP08069

实际分子量154kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情

Immunohistochemistry: 1:50~1:100

Immunohistochemical analysis of paraffin-embedded human brain tissue using IGF1R (Phospho-Tyr1346) antibody #11716 (left)or the same antibody preincubated with blocking peptide (right).
背景

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Ullrich A., EMBO J. 5:2503-2512(1986).
Abbot A.M., J. Biol. Chem. 267:10759-10763(1992).
The MGC Project Team;Genome Res. 14:2121-2127(2004).

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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