产品详情
产品名称KLK1 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC
种属反应性Human,Mouse,Rat
特异性The antibody detects endogenous level of total KLK1 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human KLK1 (NP_002248.1).
基因/蛋白名称KLK1
别名KLK1;KLKR;Klk6;hK1
数据库入口号Uniprot:P06870
GeneID:3816
UniprotP06870
Gene ID3816
实际分子量22kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using KLK1 antibody.
Immunohistochemistry of paraffin-embedded human colon carcinoma using KLK1 Rabbit pAb.
Immunohistochemistry of paraffin-embedded mouse kidney using KLK1 Rabbit pAb.
Immunohistochemistry of paraffin-embedded rat kidney using KLK1 Rabbit pAb.
背景
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
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et al,saKLK1-374 is more difficult to induce KLK1 expression in normal prostate cell lines than that in prostate cancer cell lines: Rethinking the universality of RNA activationInBiochem Biophys Res CommunOn2023 Feb 5byMengyang Zhang?1,?Dongxu Lin et al..PMID: 36610381,
, (2023),
PMID: 36610381
et al,Tissue Kallikrein Protects Rat Prostate against the Inflammatory Damage in a Chronic Autoimmune Prostatitis Model via Restoring Endothelial
Function in a Bradykinin Receptor B2-Dependent Way. In Oxid Med Cell Longev on 2022 Feb 1 by Mengyang Zhang, Dongxu Lin,et al..PMID:35154561,
, (2022),
PMID: 35154561
et al,saKLK1-374 is more difficult to induce KLK1 expression in normal prostate cell lines than that in prostate cancer cell lines: Rethinking the universality of RNA activation. In Biochem Biophys Res Commun on 2022 Dec 30 by Mengyang Zhang, Dongxu Lin,et al..PMID:36610381,
, (2022),
PMID: 36610381
et al,Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates. In Oxid Med Cell Longev on 2021 Apr 30 by Mengyang Zhang, Changcheng Luo,et al..PMID:34007408,
, (2021),
PMID: 34007408
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