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LIN28B Antibody#37362

LIN28B  Antibody
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产品总价:
产品详情

产品名称LIN28B Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antigen affinity purification.

应用WB

种属反应性Hu Ms

特异性The antibody detects endogenous levels of total LIN28B protein.

免疫原类型Peptide

免疫原描述Synthetic peptide corresponding to residues near the C terminal of human lin-28 homolog B (C. elegans)

基因/蛋白名称LIN28B

别名CSDD2

数据库入口号Swiss-Prot#: Q6ZN17
NCBI Gene ID: 389421
Gene Accssion: NP_001004317

UniprotQ6ZN17

实际分子量27kd

浓度1.6mg/ml

配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

保存Store at -20˚C

应用详情
Western blotting: 1:500-1:2000
Gel: 10%SDS-PAGE
Lysates (from left to right): Mouse liver tissue and k562 cell, hela and 293T cell
Amount of lysate: 40ug per lane
Primary antibody: 1/550 dilution
Secondary antibody dilution: 1/8000
Exposure time: 1 minute
背景
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]

如果您使用该产品37362发表了文章,请通知我们,让我们可以引用您的文献。

et al,SALL4, a novel marker for human gastric carcinogenesis and metastasis.In Oncogene on 2014 Nov 27 by L Zhang , Z Xu et al..PMID:24276240, , (2014),
PMID: 24276240
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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