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CAV1 Antibody#37401

CAV1 Antibody
CAV1 Antibody
是否有货: 有货
产品总价:
产品详情

产品名称CAV1 Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antigen affinity purification.

应用WB IHC

种属反应性Hu Ms Rt

特异性The antibody detects endogenous levels of total CAV1 protein.

免疫原类型Peptide

免疫原描述Synthetic peptide corresponding to residues near the N terminal of human caveolin 1, caveolae protein, 22kDa

基因/蛋白名称CAV1

别名CGL3; PPH3; BSCL3; VIP21; MSTP085

数据库入口号Swiss-Prot#: Q03135
NCBI Gene ID: 857
Gene Accssion: NP_001744

UniprotQ03135

实际分子量20kd

浓度2.2mg/ml

配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

保存Store at -20˚C

应用详情
Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:50-1:200
Gel: 10%SDS-PAGE
Lysates (from left to right): Human fetal muscle and fetal lung tissue, human leiomyosarcoma tissue, mouse lung and heart tissue, NIH/3T3 cell
Amount of lysate: 40ug per lane
Primary antibody: 1/550 dilution
Secondary antibody dilution: 1/8000
Exposure time: 10 seconds
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using #37401 at dilution 1/40.
背景
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

如果您使用该产品37401发表了文章,请通知我们,让我们可以引用您的文献。

et al,PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing.In Cell Death Dis.On 2018 May 1 by PMID: 29752441 , , (2018),
PMID: 29752441
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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