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位置: 首页 > 磷酸化抗体 > HER2(Phospho-Tyr1248) Antibody

HER2(Phospho-Tyr1248) Antibody#11079

HER2(Phospho-Tyr1248) Antibody
HER2(Phospho-Tyr1248) Antibody
HER2(Phospho-Tyr1248) Antibody
HER2(Phospho-Tyr1248) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称HER2(Phospho-Tyr1248) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB IHC IF

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of HER2 only when phosphorylated at tyrosine1248.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of tyrosine1248 (P-E-Y(p)-L-G) derived from Human HER2.

基因/蛋白名称HER2

修饰Phospho

别名C-erbB-2; ErbB2;

数据库入口号Swiss-Prot: P04626
NCBI Protein: NP_001005862.1

UniprotP04626

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情

Predicted MW: 185kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HER2 (Phospho-Tyr1248) Antibody #11079 (left) or the same antibody preincubated with blocking peptide #51079 (right).
Immunofluorescence staining of methanol-fixed MCF7 cells using HER2(Phospho-Tyr1248) Antibody #11079.
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using HER2 (Phospho-Tyr1248) Antibody #11079.
Western blot analysis of extracts from HepG2 cells treated with PMA and MCF cells treated with EGF, using HER2 (Phospho-Tyr1248) Antibody #11079.
背景

Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-a and amphiregulin.

Yuan,Lu Qian ,Ming Shi, et al. (2008) HER2-dependent MMP-7 expression is mediated by activated STAT3 Guogang Cellular Signalling, 20:1284

如果您使用该产品11079发表了文章,请通知我们,让我们可以引用您的文献。

Yuan Guogang, Lu Qian, Ming Shi et al,HER2-dependent MMP-7 expression is mediated by activated STAT3., Cellular Signalling, 20(7):1284篓C1291 (2008),
PMID: 18411043
et al,HER2-dependent MMP-7 Expression Is Mediated by Activated STAT3.In Cell Signal on 2008 Jul by Guogang Yuan, Lu Qian,et al..PMID:18411043 , , (2008),
PMID: 18411043
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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