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位置: 首页 > 磷酸化抗体 > Gab2 (Phospho-Tyr452) Antibody

Gab2 (Phospho-Tyr452) Antibody#12139

Gab2 (Phospho-Tyr452) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称Gab2 (Phospho-Tyr452) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous levels of Gab2 only when phosphorylated at Tyr452.

免疫原类型peptide

免疫原描述Peptide sequence around phosphorylation site of tyrosine 452 (D-N-Y(p)-V-P) derived from Human Gab2.

基因/蛋白名称Gab2

修饰Phospho

别名GRB2-associated-binding protein 2 GRB2-associated binder 2 Growth factor receptor bound protein 2-associated protein 2 pp100 GAB2 KIAA0571

数据库入口号Swiss-Prot#:Q9UQC2;
NCBI Gene#:9846

UniprotQ9UQC2

实际分子量75kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C

应用详情
Western blotting: 1:500~1:3000
Western blot analysis of extracts from JK, using Gab2 (Phospho-Tyr452) antibody #12139. The lane on the right is treated with the synthesized peptide.
背景
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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