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Ezh2 (Phospho-Thr367) Antibody#12868

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Ezh2 (Phospho-Thr367) Antibody
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产品详情

产品名称Ezh2 (Phospho-Thr367) Antibody

来源种属Rabbit

克隆性Polyclonal

应用WB

种属反应性Hu Ms Rt

特异性Phospho-Ezh2 (T367) Antibody detects endogenous levels of Ezh2 only when phosphorylated at T367

免疫原类型Peptide-KLH

免疫原描述A synthesized peptide derived from human Ezh2 (Phospho-Thr367)

别名Enhancer of zeste 2 antibody enhancer of zeste 2 polycomb repressive complex 2 subunit antibody Enhancer of zeste homolog 2 (Drosophila) antibody Enhancer of zeste homolog 2 antibody Enhancer of zeste Drosophila homolog 2 antibody ENX 1 antibody Enx 1h antibody ENX-1 antibody ENX1 antibody Enx1h antibody EZH 2 antibody EZH1 antibody EZH2 antibody EZH2_HUMAN antibody EZH2b antibody Histone-lysine N-methyltransferase EZH2 antibody KMT 6 antibody KMT6 antibody KMT6A antibody Lysine N-methyltransferase 6 antibody MGC9169 antibody WVS antibody WVS2 antibody

数据库入口号Swiss-Prot#:Q15910
NCBI Gene ID2146

计算分子量98

浓度1.0mg mL

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C

应用详情
WB dilution:1:1000
Western blot analysis Ezh2 (Phospho-Thr367) using PMA treated HeLa whole cell lysates
产品描述
The polycomb group (PcG) proteins are involved in maintaining the silenced state of several developmentally regulated genes and contribute to the maintenance of cell identity, cell cycle regulation, and oncogenesis (1,2). Enhancer of zeste homolog 2 (Ezh2), a member of this large protein family, contains four conserved regions including domain I, domain II, and a cysteine-rich amino acid stretch that precedes the carboxy-terminal SET domain (3). The SET domain has been linked with histone methyltransferase (HMTase) activity. Moreover, mammalian Ezh2 is a member of a histone deacetylase complex that functions in gene silencing, acting at the level of chromatin structure (4). Ezh2 complexes methylate histone H3 at Lys9 and 27 in vitro, which is thought to be involved in targeting transcriptional regulators to specific loci (5). Ezh2 is deregulated in various tumor types, and its role, both as a primary effector and as a mediator of tumorigenesis, has become a subject of increased interest (6).

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et al,Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein. In Nat Commun on 2021 Dec 3 by Brajendra K Tripathi, Meghan F Anderman, et al..PMID:34862367, , (2021),
PMID: 34862367
5

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注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu人
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk猴
  • Rb兔
  • B牛
  • D狗
  • P猪
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk鸡

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