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位置: 首页 > 磷酸化抗体 > perk (Phospho-Ser1094) Antibody

perk (Phospho-Ser1094) Antibody#12888

perk (Phospho-Ser1094) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称perk (Phospho-Ser1094) Antibody

来源种属Rabbit

克隆性Polyclonal

应用WB

种属反应性Hu Ms Rt

特异性Phospho-perk (S1094) Antibody detects endogenous levels of perk only when phosphorylated at S1094

免疫原类型Peptide-KLH

免疫原描述A synthesized peptide derived from human perk (Phospho-Ser1094)

别名DKFZp781H1925 antibody E2AK3_HUMAN antibody EC 2.7.11.1 antibody Eif2ak3 antibody Eukaryotic translation initiation factor 2 alpha kinase 3 antibody Eukaryotic translation initiation factor 2-alpha kinase 3 antibody Heme regulated EIF2 alpha kinase antibody HRI antibody HsPEK antibody Pancreatic eIF2 alpha kinase antibody Pancreatic eIF2-alpha kinase antibody PEK antibody PRKR like endoplasmic reticulum kinase antibody PRKR-like endoplasmic reticulum kinase antibody WRS antibody

数据库入口号Swiss-Prot#:Q9NZJ5?
NCBI Gene ID9451

计算分子量170

浓度1.0mg mL

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C

应用详情
WB dilution:1:1000
Western blot analysis perk (Phospho-Ser1094) using Jurkat whole cell lysates
产品描述
PERK (protein kinase-like endoplasmic reticulum kinase) is an eIF2α kinase and transmembrane protein resident in the endoplasmic reticulum (ER) membrane that couples ER stress signals to translation inhibition (1-3). ER stress increases the activity of PERK, which then phosphorylates eIF2α to promote reduced translation. PERK-deficient mice have defects in pancreatic β cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress (4). PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain (1-3). Phosphorylation of PERK at Thr980 serves as a marker for its activation status.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

联系我们

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Phone :

400-9961-933
025-58868422

Email Address

techcn@signalwayantibody.com