产品详情
产品名称DZIP1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用WB, IHC
种属反应性Hu
特异性The antibody detects endogenous levels of total DZIP1 protein.
免疫原类型peptide
免疫原描述Synthetic peptide of human DZIP1
基因/蛋白名称DZIP1
别名DZIP; DZIPt1
数据库入口号Swiss-Prot#:Q86YF9
NCBI Gene ID:22873
Gene Accssion:NP_945319
计算分子量99 kDa
浓度1.6mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20C
应用详情
Western blotting:1:200-1000
Immunofluorescence:1: 25-100
The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 47088(DZIP1 Antibody) at dilution 1/40. (Original magnification: ?00)
The image is immunohistochemistry of paraffin-embedded Human brain tissue using 47088(DZIP1 Antibody) at dilution 1/40. (Original magnification: ?00)
Gel: 6%SDS-PAGE
Lysate: 40 μg, Lane: PC-3 cell lysate
Primary antibody:DZIP1 Antibody at dilution 1/200
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution
Exposure time: 5 minutes
背景
DZIP1(DAZ interacting protein 1) is also known as DZIP or DZIP2 and is a 867 amino acid protein which is expressed as 3 isoforms, designated DZIPb, DZIPt1 and DZIPt2. DZIP1 is localized to testis, oocytes, ovary and fetal brain, as well as in embryonic stem cells and germ cells. In testis, DZIP1 is localized to the nucleus and also shows some cytoplasmic distribution in spermatogonia. DZIP1 belongs to the C2H2-type zinc-finger protein family, and, characteristc of the C2H2-type zinc-finger protein family, DZIP1 contains one C2H2-type zinc-finger region through which it is thought to interact with DAZ, an interaction that promotes spermiogenesis. DZIP1 expression is not found in those afflicted with Sertoli cell-only syndrome (characterized by the absence of germ cells in the testis), suggesting that the lack of DZIP1 may be involved in the pathogenesis of Sertoli cell-only syndrome-induced male sterility
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