产品详情
产品名称Human Epiregulin ELISA Kit
特异性Human
交叉反应性There is no detectable cross-reactivity with other relevant proteins.
免疫原类型E.coli, V60-L108
别名Proepiregulin; Epiregulin; EPR; EREG;
数据库入口号O14944
细胞定位 Epiregulin: Secreted, extracellular space.
应用详情
sensitivity:10pg ml
Detect Range:156pg ml-10 000pg ml
sample_type:cell culture supernates cell lysates tissue homogenates serum and plasma (heparin EDTA).
capture_antibody:monoclonal antibody from mouse
detection_antibody:polyclonal antibody from goat
gene_name:EREG
protein_name:Proepiregulin
gene_full_name:Proepiregulin
tissue_specificity: In normal adults expressed predominantly inthe placenta and peripheral blood leukocytes. High levels weredetected in carcinomas of the bladder lung kidney and colon..
sequence_similarities:
tmb_incubation:15-20min
research_category:signal transduction|growth factors/hormones|egf|cancer|tumor biomarkers
产品描述
Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Epiregulin
背景
protein_function: Ligand of the EGF receptor,EGFR and ERBB4. StimulatesEGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975).Contributes to inflammation, wound healing, tissue repair, andoocyte maturation by regulating angiogenesis and vascularremodeling and by stimulating cell proliferation(PubMed:24631357)..
Epiregulin (EPR) is a protein that in humans is encoded by the EREG gene. It is a member of the epidermal growth factor family. Epiregulin can function as a ligand of epidermal growth factor receptor (EGFR), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. The secondary structure at the C-terminus epiregulin is different from other epidermal growth factor family ligands because of the lack of hydrogen bonds. The structural difference at the C-terminus may provide an explanation for the reduced binding affinity of epiregulin to the ERBB receptors.
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