免费电话:400-9961-933
邮箱:techcn@signalwayantibody.com
欢迎光临本站
登录 注册 English
位置: 首页 > 抗体 > LAMTOR1 Antibody

LAMTOR1 Antibody#47756

LAMTOR1 Antibody
是否有货: Yes
产品总价:
产品详情

产品名称LAMTOR1 Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antigen affinity purification

应用IHC

种属反应性Hu, Ms, Rt

特异性The antibody detects endogenous levels of total LAMTOR1 protein.

免疫原类型Peptide

免疫原描述Synthetic peptide of human LAMTOR1

基因/蛋白名称LAMTOR1

别名p18; PDRO; C11orf59; p27RF-Rho; Ragulator1

数据库入口号Swiss-Prot#:Q6IAA8
NCBI Gene ID:55004
Gene Accssion:NP_060377

浓度1.3

配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

保存Store at -20˚C

应用详情

IHC dilution:1: 20-100

The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using 47756(LAMTOR1 Antibody) at dilution 1/45.(Original magnification: 200)
背景

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

如果您使用该产品47756发表了文章,请通知我们,让我们可以引用您的文献。

5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

联系我们

Location :

南京市高新开发区星火路10号人才大厦C座

Phone :

400-9961-933
025-58868422

Email Address

techcn@signalwayantibody.com