产品详情
产品名称CD8 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Immunogen affinity purified
应用WB, ICC, IHC, FC
种属反应性Ms
免疫原描述peptide
别名CD8 antibody CD8 antigen, alpha polypeptide (p32) antibody CD8a antibody CD8a antigen antibody CD8a molecule antibody CD8A_HUMAN antibody Leu2 antibody Leu2 T lymphocyte antigen antibody MAL antibody OKT8 T cell antigen antibody p32 antibody T cell antigen Leu2 antibody T cell co receptor antibody T-cell surface glycoprotein CD8 alpha chain antibody T-lymphocyte differentiation antigen T8/Leu-2 antibody T8 T cell antigen antibody
数据库入口号Swiss-Prot#:P01731
计算分子量32-36kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500
背景
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. CD8 is thought to play a role in the process of T-cell mediated killing.
背景文献
1.Liaw C.W., Zamoyska R., Parnes J.R.; "Structure, sequence, and polymorphism of the Lyt-2 T cell differentiation antigen gene."; J. Immunol. 137:1037-1043(1986). 2.Youn H.J., Harriss J.V., Gottlieb P.D.; "Nucleotide sequence analysis of the C.AKR Lyt-2a gene: structural polymorphism in alleles encoding the Lyt-2.1 T-cell surface alloantigen."; Immunogenetics 28:345-352(1988). 3.Zamoyska R., Vollmer A.C., Sizer K.C., Liaw C.W., Parnes J.R.; "Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA."; Cell 43:153-163(1985).
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et al,Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells. In Toxicol Appl Pharmacol on 2020 Oct 1 by Yuwen Sheng, Zhonghui Zhang, et al..PMID:32822738,
, (2020),
PMID: 32822738
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