产品详情
产品名称Vitamin K-dependent protein S Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Immunogen affinity purified
应用WB
种属反应性Hu
免疫原描述peptide
别名Preproprotein S antibody Propiece of latent protein S antibody PROS 1 antibody PROS antibody PROS_HUMAN antibody proS1 antibody Protein S alpha antibody Protein Sa antibody PS 21 antibody PS 22 antibody PS 23 antibody PS 24 antibody PS 25 antibody PS 26 antibody PS21 antibody PS22 antibody PS23 antibody PS24 antibody PS25 antibody PS26 antibody PSA antibody THPH5 antibody THPH6 antibody Vitamin K dependent protein S antibody Vitamin K-dependent plasma protein S antibody Vitamin K-dependent protein S antibody
数据库入口号Swiss-Prot#:P07225
计算分子量70 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
背景
Protein S is a vitamin K-dependent plasma glycoprotein synthesized in the endothelium. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b. In the plasma, circulating Protein S becomes inactive upon complexing with C4b-binding protein (C4BP); 60-70% of Protein S circulates in complex with C4BP. Its major function is as a cofactor to facilitate the action of activated protein C (APC) on its substrates, activated factor V (FVa), and activated factor VIII (FVIIIa).
背景文献
1."Molecular diversity and thrombotic risk in protein S deficiency: the PROSIT study."Protein S Italian team (PROSIT)Biguzzi E., Razzari C., Lane D.A., Castaman G., Cappellari A., Bucciarelli P., Fontana G., Margaglione M., D'Andrea G., Simmonds R.E., Rezende S.M., Preston R., Prisco D., Faioni E.M.Hum. Mutat. 25:259-269(2005) 2."Genetic and phenotypic variability between families with hereditary protein S deficiency."Rezende S.M., Lane D.A., Zoeller B., Mille-Baker B., Laffan M., Dalhbaeck B., Simmonds R.E.Thromb. Haemost. 87:258-265(2002)
Yes
