背景
The LAG1 gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. Expression of LASS2 in hepatocellular carcinoma cell lines suppresses the growth of cancer cells.The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.
背景文献
1."Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1."Pan H., Qin W.-X., Huo K.-K., Wan D.-F., Yu Y., Xu Z.-G., Hu Q.-D., Gu K.T., Zhou X.-M., Jiang H.-Q., Zhang P.-P., Huang Y., Li Y.-Y., Gu J.-R.Genomics 77:58-64(2001)
2.“Expression of LASS2 controlled by LAG1 or ADH1 promoters cannot functionally complement Lag1p” Yu, Y., Lu, H., Pan, H., Ma, J.H., Ding, Z.J. and Li, Y.Y.. Microbiol. Res. 161: 203-211.（2006）
Yes
