产品详情
产品名称DNA-PKcs/PRKDC Antibody
来源种属Mouse
克隆性Monoclonal
克隆号2-B3
纯化ProA affinity purified
应用WB, ICC, IHC
种属反应性Hu, Ms
免疫原描述recombinant protein
别名DNA dependent protein kinase catalytic subunit antibody DNA PK catalytic subunit antibody DNA-dependent protein kinase catalytic subunit antibody DNA-PK catalytic subunit antibody DNA-PKcs antibody DNAPK antibody DNAPK catalytic subunit antibody DNPK 1 antibody DNPK1 antibody Hyper radiosensitivity of murine scid mutation, complementing 1 antibody Hyperradiosensitivity complementing 1, mouse, homolog of 1 antibody HYRC 1 antibody HYRC antibody HYRC1 antibody IMD26 antibody p350 antibody p460 antibody PKRDC antibody PRKDC antibody PRKDC_HUMAN antibody Protein Kinase DNA Activated Catalytic Polypeptide antibody XRCC 7 antibody XRCC7 antibody
数据库入口号Swiss-Prot#:P78527
计算分子量～469
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
IHC: 1:200
ICC: 1:100
背景
DNA-activated serine/threonine protein kinase (DNA-PK) is a heterotrimer of PRKDC and the Ku p70-p86 (XRCC6-XRCC5) dimer. DNA-PK is a nuclear protein kinase that is involved in DNA nonhomologous end joining (NHEJ) required for double- strand brake repair and V(D)J recombination.
背景文献
1."Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA repair-defective, human, glioma-derived cell line M059J."Anderson C.W., Dunn J.J., Freimuth P.I., Galloway A.M., Allalunis-Turner M.J.Radiat. Res. 156:2-9(2001) 2."Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases."Poltoratsky V.P., Shi X., York J.D., Lieber M.R., Carter T.H.J. Immunol. 155:4529-4533(1995)
Yes
