产品详情
产品名称LMNB2 Antibody
来源种属Mouse
克隆性Monoclonal
克隆号D5-C2
纯化ProA affinity purified
应用WB, ICC
种属反应性Hu,Ms,Rt, zebrafish
免疫原描述peptide
别名LAMB 2 antibody
LAMB2 antibody
Lamin-B2 antibody
LMN 2 antibody
LMN B2 antibody
LMN2 antibody
LMNB 2 antibody
LMNB2 antibody
LMNB2_HUMAN antibody
MGC2721 antibody
RGD1563803 antibody
数据库入口号Swiss-Prot#:Q03252
计算分子量68 kDa
配方1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
ICC: 1:200-1:500
背景
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
背景文献
1."Sequencing of the reannotated LMNB2 gene reveals novel mutations in patients with acquired partial lipodystrophy." Hegele R.A., Cao H., Liu D.M., Costain G.A., Charlton-Menys V., Rodger N.W., Durrington P.N. Am. J. Hum. Genet. 79:383-389(2006)
2."System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011)