产品详情
产品名称Cathepsin B Antibody
来源种属Mouse
克隆性Monoclonal
克隆号J11-A11
纯化ProA affinity purified
应用WB, ICC, IHC
种属反应性Hu, zebrafish
免疫原描述recombinant protein
别名Amyloid precursor protein secretase antibody
APP secretase antibody
APPS antibody
CATB_HUMAN antibody
Cathepsin B heavy chain antibody
Cathepsin B1 antibody
CathepsinB antibody
CPSB antibody
CTSB antibody
cysteine protease antibody
OTTHUMP00000116009 antibody
OTTHUMP00000229510 antibody
OTTHUMP00000229511 antibody
OTTHUMP00000229512 antibody
OTTHUMP00000229514 antibody
OTTHUMP00000229515 antibody
OTTHUMP00000229516 antibody
Preprocathepsin B antibody
数据库入口号Swiss-Prot#:P07858
计算分子量38kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:5,000-1:10,000
ICC: 1:200-1:500
背景
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. In humans, it is coded by the CTSB gene. A wide array of diseases results in elevated levels of cathepsin B, which causes numerous pathological processes including cell death, inflammation, and production of toxic peptides. Focusing on neurological diseases, cathepsin B gene knockout studies in an epileptic rodent model have shown cathepsin B causes a significant amount of the apoptotic cell death that occurs as a result of inducing epilepsy. Mutations in the CTSB gene have been linked to tropical pancreatitis, a form of chronic pancreatitis.
背景文献
1.Tandon RK (January 2007). "Tropical pancreatitis". J. Gastroenterol. 42 (Suppl 17): 141–7.
2.Klein, D.M.; Felsentein, K.M.; Brenneman, D.E. (2009). "Cathepsins B and L differentially regulate amyloid precursor protein processing". J Pharmacol Exp Ther 329 (3): 813–21.
3.Kindy, M.S.; Yu, J.; Zhu, H.; El-Amouri, S.S.; Hook, V.; Hook, G.R. (2012). "Deletion of the Cathepsin B Gene Improves Memory Deficits in a Transgenic Alzheimer's Disease Mouse Model Expressing AbetaPP Containing the Wild-Type beta-Secretase Site Sequence". J Alzheimers Dis 29 (4): 827–40.
如果您使用该产品48118发表了文章，请通知我们，让我们可以引用您的文献。
et al,Coprophagy Prevention Decreases the Reproductive Performance and Granulosa Cell Apoptosis via Regulation of CTSB Gene in Rabbits. In Front Physiol
on 2022 Jul 18 by Guohua Song, Yadong Wang, et al..PMID:35923240,
, (2022),
PMID: 35923240
Yes
