产品详情
产品名称VEGFC Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Immunogen affinity purified
应用WB
种属反应性Hu
免疫原描述peptide
别名Flt 4L antibody Flt4 ligand antibody FLT4 ligand DHM antibody Flt4-L antibody Flt4L antibody Vascular endothelial growth factor C antibody Vascular endothelial growth factor related protein antibody Vascular endothelial growth factor-related protein antibody VEGF C antibody VEGF-C antibody Vegfc antibody VEGFC_HUMAN antibody VRP antibody
数据库入口号Swiss-Prot#:P49767
计算分子量46 kDa
配方1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
背景
VEGF-A plays a paramount role in tumor angiogenesis, VEGF-C has been characterized as an essential lymphangiogenic factor that promotes cancer metastasis. VEGF-C is a ligand for both VEGF-R3 and VEGF-R2 but has a high affinity for VEGF-R3. It has been reported that the VEGF-C/VEGF-R3 axis is activated in subsets of leukemia patients.
背景文献
1."Structural determinants of growth factor binding and specificity by VEGF receptor 2." Leppanen V.M., Prota A.E., Jeltsch M., Anisimov A., Kalkkinen N., Strandin T., Lankinen H., Goldman A., Ballmer-Hofer K., Alitalo K.Proc. Natl. Acad. Sci. U.S.A. 107:2425-2430(2010) 2."Proteolytic processing regulates receptor specificity and activity of VEGF-C." Joukov V., Sorsa T., Kumar V., Jeltsch M., Claesson-Welsh L., Cao Y., Saksela O., Kalkkinen N., Alitalo K.EMBO J. 16:3898-3911(1997)
Yes
