产品详情
产品名称L1ORF1p Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Peptide affinity purified
应用WB, ICC
种属反应性Ms
免疫原描述peptide
别名L12R1_HUMAN antibody loh12cr1 antibody Loss of heterozygosity 12 chromosomal region 1 protein antibody
数据库入口号Swiss-Prot#:P11260
计算分子量41 kDa
配方1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
ICC: 1:50-1:100
背景
The L1 (LINE 1) retrotransposable element encodes two proteins, ORF1p and ORF2p. Mouse ORF1p, a coiled-coil-mediated trimer of 42-kDa monomers. It may function as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.
背景文献
1.Martin S.L., Bushman F.D. Mol. Cell. "Nucleic acid chaperone activity of the ORF1 protein from the mouse LINE-1 retrotransposon." Biol. 21:467-475(2001) 2."Trimeric structure for an essential protein in L1 retrotransposition." Martin S.L., Branciforte D., Keller D., Bain D.L. Proc. Natl. Acad. Sci. U.S.A. 100:13815-13820(2003) 3."Identification and solution structure of a highly conserved C-terminal domain within ORF1p required for retrotransposition of long interspersed nuclear element-1." Januszyk K., Li P.W., Villareal V., Branciforte D., Wu H., Xie Y., Feigon J., Loo J.A., Martin S.L., Clubb R.T. J. Biol. Chem. 282:24893-24904(2007)
Yes
