产品详情
产品名称IL1RAPL1 Antibody
来源种属Mouse
纯化ProA affinity purified
应用WB, ICC, FC
种属反应性Hu
免疫原描述Recombinant protein
别名IL 1 RAPL 1 antibody
IL 1RAPL 1 antibody
IL-1-RAPL-1 antibody
IL-1RAPL-1 antibody
IL1R8 antibody
IL1RAPL 1 antibody
IL1RAPL antibody
IL1RAPL-1 antibody
IL1RAPL1 antibody
Interleukin 1 receptor 8 antibody
Interleukin 1 receptor accessory protein like 1 antibody
Interleukin-1 receptor accessory protein-like 1 antibody
IRPL1_HUMAN antibody
Mental retardation X linked 10 antibody
Mental retardation X linked 21 antibody
Mental retardation X linked 34 antibody
MRX 21 antibody
MRX 34 antibody
MRX10 antibody
MRX21 antibody
MRX34 antibody
Oligophrenin 4 antibody
Oligophrenin-4 antibody
Oligophrenin4 antibody
OPHN 4 antibody
OPHN4 antibody
Three immunoglobulin domain containing IL 1 receptor related 2 antibody
Three immunoglobulin domain-containing IL-1 receptor-related 2 antibody
TIGIRR 2 antibody
TIGIRR-2 antibody
TIGIRR2 antibody
X linked interleukin 1 receptor accessory protein like 1 antibody
X-linked interleukin-1 receptor accessory protein-like 1 antibody
数据库入口号Swiss-Prot#:Q9NZN1
计算分子量80 kDa
浓度2.0 ug/ul
配方Purified antibody in PBS with 0.05% sodium azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:2,000
ICC: 1:50-1:200
FC: 1:100-1:200
Western blot analysis of IL1RAPL1 on ?human IL1RAPL1 recombinant protein using anti-IL1RAPL1 antibody at 1/1,000 dilution.
Western blot analysis of IL1RAPL1 on HEK293 (1) and IL1RAPL1-hIgGFc transfected HEK293 (2) cell lysate using anti-IL1RAPL1 antibody at 1/1,000 dilution.
Western blot analysis of IL1RAPL1 on different cell lysate using anti-IL1RAPL1 antibody at 1/1,000 dilution. Positive control�� Lane1: A431 Lane2: SK-Hep-1 Lane3: HL-7702
ICC staining IL1RAPL1 (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of Hela cells with IL1RAPL1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
背景
May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities.
1. Montani C et al. The X-Linked Intellectual Disability Protein?IL1RAPL1?Regulates Dendrite Complexity.J Neurosci 37(28):6606-6627 (2017).
2. Laino L et al. Clinical and molecular characterization of a boy with intellectual disability, facial dysmorphism, minor digital anomalies and a complex?IL1RAPL1?intragenic rearrangement.Eur J Paediatr Neurol 20(6):971-976 (2015).
Yes
