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位置: 首页 > 抗体 > MSH6 Antibody

MSH6 Antibody#48563

MSH6 Antibody
MSH6 Antibody
MSH6 Antibody
MSH6 Antibody
是否有货: Yes
产品总价:
产品详情

产品名称MSH6 Antibody

来源种属Rabbit

克隆性Monoclonal

纯化Affinity-chromatography

应用WB IHC CC/IF

种属反应性Hu Ms Rt

免疫原描述peptide

别名DNA mismatch repair protein Msh6 antibody
G/T mismatch binding protein antibody
G/T mismatch-binding protein antibody
GTBP antibody
GTMBP antibody
hMSH6 antibody
HNPCC 5 antibody
HNPCC5 antibody
HSAP antibody
MSH 6 antibody
MSH6 antibody
MSH6_HUMAN antibody
mutS (E. coli) homolog 6 antibody
MutS alpha 160 kDa subunit antibody
MutS homolog 6 (E. coli) antibody
mutS homolog 6 antibody
MutS-alpha 160 kDa subunit antibody
p160 antibody
Sperm associated protein antibody

数据库入口号Swiss-Prot#:P52701

计算分子量Calculated Mol Weight 153 kDa Observed Mol Weight 163 kDa

配方Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

保存Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

应用详情

WB 1:1000-1:2000
IHC 1:100-1:200
ICC/IF 1:50-1:200

Western blot analysis of MSH6 in SW480 cell lysate.
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using MSH6 Antibody.
Immunofluorescent analysis using the Antibody at 1:50 dilution.(HELA)
背景
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA.
背景文献

1. "GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells." Palombo F., Gallinari P., Iaccarino I., Lettieri T., Hughes M., D'Arrigo A., Truong O., Hsuan J.J., Jiricny J. Science 268:1912-1914(1995) 2. "MSH6 missense mutations are often associated with no or low cancer susceptibility." Kariola R., Hampel H., Frankel W.L., Raevaara T.E., de la Chapelle A., Nystroem-Lahti M. Br. J. Cancer 91:1287-1292(2004)

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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400-9961-933
025-58868422

Email Address

techcn@signalwayantibody.com