产品详情
产品名称ZO1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Peptide affinity purified
应用ICC, IHC
种属反应性Hu, Ms, Rt
免疫原描述peptide
别名Tight junction protein 1 antibody Tight junction protein ZO-1 antibody Tight junction protein ZO1 antibody TJP1 antibody zo-1 antibody Zo1 antibody ZO1_HUMAN antibody Zona occludens 1 antibody Zona occludens 1 protein antibody Zona occludens protein 1 antibody Zonula occludens 1 protein antibody Zonula occludens protein 1 antibody
数据库入口号Swiss-Prot#:Q07157
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
IHC: 1:200
ICC: 1:200
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-ZO1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-ZO1 antibody. Counter stained with hematoxylin.
ICC staining ZO1 in MCF-7 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
背景
Tight junction protein ZO-1 is a protein that in humans is encoded by the TJP1 gene. This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. ZO1 plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.
背景文献
1. "Evidence for a functional interaction between cingulin and ZO-1 in cultured cells." D'Atri F., Nadalutti F., Citi S. J. Biol. Chem. 277:27757-27764(2002) 2. "Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells." Sallee J.L., Burridge K. J. Biol. Chem. 284:14997-15006(2009) 3. "Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration." Huo L., Wen W., Wang R., Kam C., Xia J., Feng W., Zhang M. EMBO J. 30:665-678(2011)
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et al,Bacterial endotoxin-induced maternal inflammation leads to fetal intestinal injury and affects microbial colonization in the neonatal period. In J Matern Fetal Neonatal Med
on 2021 May 31 by Qingmei Huang, Siliang Lu,et al..PMID:34058958,
, (2021),
PMID: 34058958
et al,Lipopolysaccharide-Induced Chorioamnionitis Induces Fetal Intestinal Injury and Affects Gut Colonization in Rats
,
, (2020),
PMID:
Yes
