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位置： 首页 > 重组兔单抗 > PI 3 Kinase catalytic subunit alpha Rabbit mAb

PI 3 Kinase catalytic subunit alpha Rabbit mAb#48751

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Recombinant
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PI 3 Kinase catalytic subunit alpha Rabbit mAb
PI 3 Kinase catalytic subunit alpha Rabbit mAb
PI 3 Kinase catalytic subunit alpha Rabbit mAb
是否有货： Yes
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产品详情

产品名称PI 3 Kinase catalytic subunit alpha Rabbit mAb

克隆号SJ0186

纯化ProA affinity purified

应用WB, ICC/IF, IP

种属反应性Human Rat Mouse

免疫原描述recombinant protein

别名5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha antibody
5-bisphosphate 3-kinase catalytic subunit alpha isoform antibody
caPI3K antibody
CLOVE antibody
CWS5 antibody
MCAP antibody
MCM antibody
MCMTC antibody
MGC142161 antibody
MGC142163 antibody
p110 alpha antibody
p110alpha antibody
Phosphatidylinositol 3 kinase catalytic alpha polypeptide antibody
Phosphatidylinositol 3 kinase catalytic 110 KD alpha antibody
Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha antibody
Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform antibody
Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha antibody
Phosphatidylinositol-4 antibody
Phosphoinositide 3 kinase catalytic alpha polypeptide antibody
PI3 kinase p110 subunit alpha antibody
PI3-kinase subunit alpha antibody
PI3K antibody
PI3K-alpha antibody
PI3KC A antibody
PIK3C A antibody
Pik3ca antibody
PK3CA antibody
PK3CA_HUMAN antibody
PtdIns 3 kinase p110 antibody
PtdIns-3-kinase subunit alpha antibody
PtdIns-3-kinase subunit p110-alpha antibody
Serine/threonine protein kinase PIK3CA antibody

数据库入口号Swiss-Prot#:P42336

计算分子量124 kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情

WB: 1:500-1:1000

ICC: 1:50-1:200

ICC staining PI 3 kinase p110 alpha in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining PI 3 kinase p110 alpha in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining PI 3 kinase p110 alpha in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
背景

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110δ expression is restricted to white blood cells. It has been shown to bind p85α and β, but it apparently does not phosphorylate these subunits. p110δ seems to have the capacity to autophosphorylate. p110γ does not interact with the p85 subunits. It has been shown to be activated by α and βγ heterotrimeric G proteins.

背景文献

1. Salm, F. et al. 2015. The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma. PloS one. 10: e0123958.
2. Akula, M.K. et al. 2016. Control of the innate immune response by the mevalonate pathway. Nature immunology. 17: 922-9.

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5

操作手册

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu人
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk猴
  • Rb兔
  • B牛
  • D狗
  • P猪
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk鸡

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