产品详情
产品名称DGCR8 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号ST04-79
纯化ProA affinity purified
应用WB, ICC/IF, IP
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
别名DGCRK6 antibody C22orf12 antibody D16H22S788E antibody D16Wis2 antibody DGCR 8 antibody Dgcr8 antibody DGCR8 microprocessor complex subunit antibody DGCR8_HUMAN antibody DGCRK 6 antibody DiGeorge syndrome critical region 8 antibody DiGeorge syndrome critical region gene 8 antibody Gy1 antibody Microprocessor complex subunit DGCR8 antibody pasha antibody
数据库入口号Swiss-Prot#:Q8WYQ5
计算分子量100 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
ICC: 1:50-1:200
Western blot analysis of DGCR8 on different lysates using anti-DGCR8 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: PC12 Lane 3: NIH/3T3
ICC staining DGCR8 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining DGCR8 in PC12 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
背景
DGS8, also designated DiGeorge syndrome critical region 8 protein, plays a role in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS). It is a ubiquitously expressed protein encoded by the gene DGCR8, which is deleted in DiGeorge syndrome. DiGeorge syndrome is characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies. In mouse, DGS8 is detected primarily in embryonic brain, vessels, thymus and palate.
背景文献
1. Ho, JJ. et al. 2012. Functional importance of dicer protein in the adaptive cellular response to hypoxia. J. Biol. Chem. 287: 29003-29020. 2. Bellemer, C. et al. 2012. Microprocessor dynamics and interactions at endogenous imprinted C19MC microRNA genes. J. Cell. Sci. 125: 2709-2720.
Yes
