产品详情
产品名称NLRP3 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号SC06-23
纯化ProA affinity purified
应用WB, ICC/IF, IHC, IP, FC
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
别名AGTAVPRL antibody
AII/AVP antibody
Angiotensin/vasopressin receptor AII/AVP like antibody
Angiotensin/vasopressin receptor AII/AVP-like antibody
C1orf7 antibody
Caterpiller protein 1.1 antibody
CIAS 1 antibody
CIAS1 antibody
CLR1.1 antibody
Cold autoinflammatory syndrome 1 antibody
Cold autoinflammatory syndrome 1 protein antibody
Cryopyrin antibody
Familial cold autoinflammatory syndrome antibody
FCAS antibody
FCU antibody
LRR and PYD domains-containing protein 3 antibody
Muckle-Wells syndrome antibody
MWS antibody
NACHT antibody
NACHT LRR and PYD containing protein 3 antibody
NALP 3 antibody
NALP3 antibody
NALP3_HUMAN antibody
NLRP3 antibody
PYPAF 1 antibody
PYPAF1 antibody
PYRIN containing APAF1 like protein 1 antibody
PYRIN-containing APAF1-like protein 1 antibody
数据库入口号Swiss-Prot#:Q96P20
计算分子量118/85 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:100-1:500
FC: 1:50-1:100
背景
Cryopyrin interacts selectively with apoptosis-associated specklike protein containing a CARD domain (ASC). This complex may function as an upstream activator of NFkB signaling and caspase-1 activation. The complex also inhibits TNFa induced activation and nuclear translocation of RelA/NFkB p65. Mutations in Cryopyrin and Pyrin proteins are responsible for several autoinflammatory disorders in humans, including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurologic cutaneous and articular syndrome (CINCA).
背景文献
1. Qiao J et al. Busulfan and cyclosphamide induce liver inflammation through NLRP3 activation in mice after hematopoietic stem cell transplantation. Sci Rep 5:17828 (2015).
2. Ataide MA et al. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog 10:e1003885 (2014).
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et al,Ginsenoside Rk3 alleviated DSS-induced ulcerative colitis by protecting colon barrier and inhibiting NLRP3 inflammasome pathway. In Int Immunopharmacol on 2020 Aug by Mi Tian, Pei Ma, et al..PMID: 32521491,
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