产品详情
产品名称Delta Opioid Receptor Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号SN20-04
纯化ProA affinity purified
应用WB, FC
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
别名D-OR-1 antibody Delta type opioid receptor antibody Delta type opioid receptor DOR 1 antibody Delta type opioid receptor DOR1 antibody Delta-type opioid receptor antibody DOR 1 antibody DOR-1 antibody DOR1 antibody mDOR antibody Nbor antibody Opioid receptor delta 1 antibody OPRD 1 antibody OPRD antibody OPRD_HUMAN antibody Oprd1 antibody
数据库入口号Swiss-Prot#:P41143
计算分子量40 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
FC: 1:50-1:100
背景
Endogenous opioid peptides and opiates, like morphine, transmit their pharmacological effects through membrane bound opioid receptors. Pharmacological studies and molecular cloning have led to the identification of three different types of opioid receptor, mu-type, delta-type and kappa-type, also designated MOR-1, DOR-1 and KOR-1, respectively. MOR-1 is a receptor for beta-endorphin, DOR-1 is a receptor for enkephalins, and KOR-1 is a receptor for dynorphins. The three opioid receptor types are highly homologous and belong to the superfamily of G protein-coupled receptors. Opioid receptors have been shown to modulate a range of brain functions, including instinctive behavior and emotions. This regulation is thought to involve the inhibition of neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.
背景文献
1. Ju, J. et al. 2013. Role of spinal opioid receptor on the antiallodynic effect of intrathecal nociceptin in neuropathic rat. Neurosci. Lett.. 542: 118-122. 2. De Minicis, S. et al. 2008. Role of endogenous opioids in modulating HSC activity in vitro and liver fibrosis in vivo. Gut. 57: 352-364.
Yes
