产品详情
产品名称ZNRF2 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号JJ0924
纯化ProA affinity purified
应用WB, IHC
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
别名E3 ubiquitin-protein ligase ZNRF2 antibody Protein Ells2 antibody RING finger protein 202 antibody RNF202 antibody Zinc/RING finger protein 2 antibody Znrf2 antibody ZNRF2_HUMAN antibody
数据库入口号Swiss-Prot#:Q8NHG8
计算分子量24 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
背景
NF-E2 related factor 2 (Nrf2) is a member of the cap ��n�� collar family of basic leucine zipper transcription factors. By binding antioxidant response elements (AREs), Nrf2 activates the transcription of genes encoding antioxidant and phase II drug-metabolizing enzymes needed to protect cells against oxidative damage. Transcriptional targets regulated by Nrf2 include genes encoding glutathione S-transferases, superoxide dismutase-1, and heme oxygenase-1.
背景文献
1. Hoxhaj G., et al. 2012. ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125:4662-4675. 2. Bian Y., et al. 2014. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics 96:253-262.
Yes
