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位置: 首页 > 重组兔单抗 > Phospho-Smad2(S255) Rabbit mAb

Phospho-Smad2(S255) Rabbit mAb#13429

评价
Recombinant
是否有货: Yes
产品总价:
产品详情

产品名称Phospho-Smad2(S255) Rabbit mAb

来源种属Rabbit

克隆性Monoclonal

克隆号JF0882

纯化ProA affinity purified

应用WB, IHC, IP

种属反应性Hu, Ms, Rt

免疫原描述Synthetic phospho-peptide corresponding to residues surrounding Ser255 of human Smad2.

别名Drosophila, homolog of, MADR2 antibody
hMAD-2 antibody
HsMAD2 antibody
JV18 antibody
JV18-1 antibody
JV181 antibody
MAD antibody
MAD homolog 2 antibody
MAD Related Protein 2 antibody
Mad-related protein 2 antibody
MADH2 antibody
MADR2 antibody
MGC22139 antibody
MGC34440 antibody
Mother against DPP homolog 2 antibody
Mothers against decapentaplegic homolog 2 antibody
Mothers against decapentaplegic, Drosophila, homolog of, 2 antibody
Mothers against DPP homolog 2 antibody
OTTHUMP00000163489 antibody
Sma and Mad related protein 2 antibody
Sma- and Mad-related protein 2 MAD antibody
SMAD 2 antibody
SMAD family member 2 antibody
SMAD, mothers against DPP homolog 2 antibody
SMAD2 antibody
SMAD2_HUMAN antibody

数据库入口号Swiss-Prot#:Q15796

计算分子量52 kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情

WB: 1:1,000
IHC: 1:50-1:200
 

背景

Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad proteins.

背景文献

1. Ungefroren H et al. Rac1b negatively regulates TGF-?1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling. Oncotarget 5:277-90 (2014).
2. Harazono Y et al. miR-655 Is an EMT-suppressive MicroRNA targeting ZEB1 and TGFBR2. PLoS One 8:e62757 (2013).

如果您使用该产品13429发表了文章,请通知我们,让我们可以引用您的文献。

et al,Gastrodin attenuates renal injury and collagen deposition via suppression of the TGF-β1/Smad2/3 signaling pathway based on network pharmacology analysis InFront PharmacolOn2023 Jan 17byYing Wen , Xiuli Zhang et al..PMID:36733505, , (2023),
PMID: 36733505
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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