产品详情
产品名称L1CAM Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号JM11-05
纯化ProA affinity purified
应用WB, IHC
种属反应性Hu
免疫原描述recombinant protein
别名Antigen identified by monoclonal antibody
R1 antibody
CAML1 antibody
CD171 antibody
CD171 antigen antibody
HSAS antibody
HSAS1 antibody
Hyd antibody
L1 antibody
L1 cell adhesion molecule antibody
L1-NCAM antibody
L1cam antibody
L1CAM_HUMAN antibody
MASA antibody
MIC5 antibody
N CAML1 antibody
N-CAM-L1 antibody
NCAM-L1 antibody
NCAML1 antibody
Nerve-growth factor-inducible large external glycoprotein antibody
Neural cell adhesion molecule L1 antibody
NILE antibody
OTTHUMP00000025992 antibody
S10 antibody
SPG1 antibody
数据库入口号Swiss-Prot#:P32004
计算分子量85/250 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-5,000
IHC: 1:50-1:200
Western blot analysis of L1CAM on different cells lysates using anti-L1CAM antibody at 1/500 dilution. Positive control��
Line 1: Hela
Line 2: human brain
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-L1CAM antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human thyroid tissue using anti-L1CAM antibody. Counter stained with hematoxylin.
背景
Cell adhesion molecules are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are thought to play an important role in embryogenesis and development. Neuronal cell adhesion molecule (NCAM) expression is observed in a variety of human tumors, including neuroblastomas, rhabdomyosarcomas, Wilm's tumors, Ewing's sarcomas and some primitive myeloid malignancies. The NCAM-L1 adhesion molecule (CD171) plays an important role in axon guidance and cell migration in the nervous system. The presence of NCAM-L1 might contribute to tumor progression by promoting cell adhesion and migration and is known to be expressed by neurons, neuroblastomas and other malignant tumors.
背景文献
1. Fu TG et al. miR-143 inhibits oncogenic traits by degrading NUAK2 in glioblastoma. Int J Mol Med 37:1627-35 (2016). 2. Yoo M et al. Analysis of human embryonic stem cells with regulatable expression of the cell adhesion molecule l1 in regeneration after spinal cord injury. J Neurotrauma 31:553-64 (2014).
Yes
