产品详情
产品名称RPE65 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号JM61-51
纯化ProA affinity purified
应用WB, IP
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
别名All-trans-retinyl-palmitate hydrolase antibody
LCA 2 antibody
LCA2 antibody
Leber congenital amaurosis antibody
mRPE 65 antibody
mRPE65 antibody
p63 antibody
rd 12 antibody
rd12 antibody
Retinal pigment epithelium specific 61 kDa protein antibody
Retinal pigment epithelium specific 65 kDa protein antibody
Retinal pigment epithelium specific protein antibody
Retinal pigment epithelium specific protein 65kDa antibody
Retinal pigment epithelium-specific 65 kDa protein antibody
Retinitis pigmentosa 20 antibody
Retinoid isomerohydrolase antibody
Retinol isomerase antibody
RP 20 antibody
RP20 antibody
RPE 65 antibody
RPE65 antibody
RPE65_HUMAN antibody
sRPE 65 antibody
sRPE65 antibody
数据库入口号Swiss-Prot#:Q16518
计算分子量61 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
IP: 1:10-1:50
背景
The retinal pigment epithelium (RPE) is a monolayer simple epithelium in proximity to the outer surface of the retinal photoreceptor cells. Retinal pigment epithelium-specific protein (RPE65) is a 65kDa protein belonging to the beta-carotene dioxygenase family. This protein is important in 11-cis retinal production as well as in visual pigment regeneration. RPE65 is attached to the membrane by a lipid anchor when palmitoylated (membrane form) and soluble when unpalmitoylated. The soluble form of the protein binds vitamin A. Defects in RPE65 causes autosomal dominant retinitis pigmentosa and/or Leber congenital amaurosis type 2.
背景文献
1. Zhou J et al. Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition. J Biol Chem 290:27215-27 (2015). 2. Sukseree S et al. Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice. PLoS One 11:e0161640 (2016).
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