产品详情
产品名称Lin28 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号JA10-63
纯化ProA affinity purified
应用WB, IP, FC
种属反应性Hu
免疫原描述recombinant protein
别名AL024421 antibody
CSDD1 antibody
CSDD2 antibody
FLJ12457 antibody
Lin 28 antibody
Lin 28 homolog (C. elegans) antibody
Lin 28 homolog A (C. elegans) antibody
Lin 28 homolog A antibody
Lin 28 homolog antibody
Lin-28A antibody
Lin28 antibody
Lin28, C. elegans, homolog of, A antibody
LIN28A antibody
LN28A_HUMAN antibody
Protein lin-28 homolog A antibody
Protein lin-28 homolog B antibody
RNA binding protein lin 28 antibody
Tex17 antibody
ZCCHC1 antibody
Zinc finger CCHC domain containing 1 antibody
Zinc finger CCHC domain containing protein 1 antibody
Zinc finger CCHC domain-containing protein 1 antibody
数据库入口号Swiss-Prot#:Q9H9Z2
计算分子量23 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:1,000
IP: 1:10-1:50
FC: 1:50-1:100
背景
LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein sysnthesis efficiency and binds to the growth and differentiation factor IGF-II.
背景文献
1. Vessoni AT et al. Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony. Hum Mol Genet 25:1271-80 (2016).
2. Al-Lamki RS et al. Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma. Oncotarget 7:24111-24 (2016).
Yes
