产品详情
产品名称Lipoprotein lipase Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号JA22-02
纯化ProA affinity purified
应用WB, IHC
种属反应性Hu
免疫原描述recombinant protein
别名EC 3.1.1 antibody
EC 3.1.1.34 antibody
HDLCQ11 antibody
LIPD antibody
LIPL_HUMAN antibody
Lipoprotein lipase antibody
LPL antibody
LPL protein antibody
MGC137861 antibody
数据库入口号Swiss-Prot#:P06858
计算分子量53 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:1,000
IHC: 1:50-1:200
Western blot analysis of Lipoprotein lipase on human placenta tissue lysate using anti-Lipoprotein lipase antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human ileum tissue using anti-Lipoprotein lipase antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Lipoprotein lipase antibody. Counter stained with hematoxylin.
背景
The Lipase gene family belongs to one of the most robust genetic superfamilies found in living organisms, which includes esterases and thioesterases. Lipase gene products are related by tertiary structure rather than primary amino acid sequence. Members of the AB hydrolase subfamily include hepatic lipase (HL), endothelial lipase (EL), lipoprotein lipase (LPL) and pancreatic lipase (PL). HL balances the composition and transport of lipoproteins in human plasma. Synthesized in endothelial cells, EL hydrolyzes high density lipoproteins. LPL, a homodimer attached to the membrane by a GPI-anchor, mediates the hydrolysis of triglycerides of very low density lipoproteins and circulating chylomicrons. Defects in LPL may cause chylomicronemia syndrome or a form of lipoprotein lipase deficiency characterized by hypertriglyceridemia.
背景文献
1. Bal NC ?et al.?Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function.?J Biol Chem?291:17247-57 (2016).
? 2. Alfaradhi MZ ?et al.?Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity.?Am J Physiol Regul Integr Comp Physiol?307:R26-34 (2014).
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Yes
