产品详情
产品名称LXR alpha Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号JA20-38
纯化ProA affinity purified
应用WB, ICC, IHC, FC
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
别名Liver X receptor alpha antibody
LXR a antibody
LXRA antibody
NR1H3 antibody
NR1H3_HUMAN antibody
Nuclear receptor subfamily 1 group H member 3 antibody
Oxysterols receptor LXR alpha antibody
Oxysterols receptor LXR-alpha antibody
RLD 1 antibody
RLD1 antibody
数据库入口号Swiss-Prot#:Q13133
计算分子量50 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500
IHC: 1��50-1��200
FC: 1:50-1:100
Western blot analysis of LXR alpha on mouse colon tissue lysate using anti-LXR alpha antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-LXR alpha antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse testes tissue using anti-LXR alpha antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-LXR alpha antibody. Counter stained with hematoxylin.
ICC staining LXR alpha in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of HepG2 cells with LXR alpha antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
背景
Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
Yes
