产品详情
产品名称DR5 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号JA03-38
纯化ProA affinity purified
应用WB, IP, IHC, FC
种属反应性Hu
免疫原描述recombinant protein
别名Fas like protein antibody
Apoptosis inducing protein TRICK2A/2B antibody
Apoptosis inducing receptor TRAIL R2 antibody
CD262 antibody
CD262 antigen antibody
Cytotoxic TRAIL receptor 2 antibody
Death domain containing receptor for TRAIL/Apo 2L antibody
Death receptor 5 antibody
DR5 antibody
KILLER antibody
KILLER/DR5 antibody
OTTHUMP00000123492 antibody
OTTHUMP00000123493 antibody
p53 regulated DNA damage inducible cell death receptor(killer) antibody
TNF related apoptosis inducing ligand receptor 2 antibody
TNF-related apoptosis-inducing ligand receptor 2 antibody
TNFRSF10B antibody
TR10B_HUMAN antibody
TRAIL R2 antibody
TRAIL receptor 2 antibody
TRAIL-R2 antibody
TRAILR2 antibody
TRICK2 antibody
TRICK2A antibody
TRICK2B antibody
TRICKB antibody
Tumor necrosis factor receptor like protein ZTNFR9 antibody
Tumor necrosis factor receptor superfamily member 10B antibody
Tumor necrosis factor receptor superfamily, member 10b antibody
ZTNFR9 antibody
数据库入口号Swiss-Prot#:O14763
计算分子量48 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:1,000
IHC: 1:50-1:200
FC: 1:50-1:100
Western blot analysis of DR5 on HL-60 cell using anti-DR5 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-DR5 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-DR5 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-DR5 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-DR5 antibody. Counter stained with hematoxylin.
Flow cytometric analysis of SW480 cells with DR5 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
背景
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes FAS antigen and CD40. TNF-R1 contains a cytoplasmic motif, termed the "death domain," that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors, including FAS, DR2 (or TRUNDD), DR3 (Death Receptor 3), DR4 and DR5. TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor, designated decoy receptor (DcR1 or TRID), also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli.
Yes
