产品详情
产品名称GluR2 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号JU20-43
纯化ProA affinity purified
应用WB,ICC,IF,IHC,IP
种属反应性Hu, Ms, Rt
免疫原描述Recombinant protein
别名AMPA 2 antibody
AMPA selective glutamate receptor 2 antibody
AMPA-selective glutamate receptor 2 antibody
AMPA2 antibody
GluA2 antibody
GLUR 2 antibody
GLUR B antibody
GluR K2 antibody
GluR-2 antibody
GluR-B antibody
GluR-K2 antibody
GLUR2 antibody
GLURB antibody
Glutamate receptor 2 antibody
Glutamate receptor ionotropic AMPA 2 antibody
Glutamate receptor ionotropic antibody
Gria2 antibody
GRIA2_HUMAN antibody
HBGR2 antibody
数据库入口号Swiss-Prot#:P42262
计算分子量110 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
IHC: 1:50-1:200
ICC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-GluR2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-GluR2 antibody. Counter stained with hematoxylin.
ICC staining GluR2 in N2A cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining GluR2 in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
背景
Lonotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
背景文献
1. Lam RS et al. Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term Cultures. PLoS One 12:e0169506 (2017).
2. Li WG et al. ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nat Commun 7:13770 (2016).
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et al,Butyric acid precursor tributyrin modulates hippocampal synaptic plasticity and prevents spatial memory deficits: role of PPARγ and AMPK. In Int J Neuropsychopharmacol on 2022 Jun 21 by Ana Belén Sanz-Martos, Jesús Fernández-Felipe, et al..PMID:35152284,
, (2022),
PMID: 35152284
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