产品详情
产品名称SCGB1A1 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号JU34-03
纯化ProA affinity purified
应用WB,ICC,FC
种属反应性Hu, Ms, Rt
免疫原描述Recombinant protein
别名Blastokinin antibody
CC10 antibody
CC16 antibody
CCPBP antibody
CCSP antibody
Clara cell phospholipid binding protein antibody
Clara cell phospholipid-binding protein antibody
Clara cell specific 10 kD protein antibody
Clara cells 10 kDa secretory protein antibody
OTTHUMP00000236107 antibody
SCGB1A1 antibody
Secretoglobin family 1A member 1 antibody
Secretoglobin, family 1A, member 1 (uteroglobin) antibody
UG antibody
UGB antibody
UP-1 antibody
UP1 antibody
Urinary protein 1 antibody
Urine protein 1 antibody
UTER_HUMAN antibody
Uteroglobin antibody
数据库入口号Swiss-Prot#:P11684
计算分子量10 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:1,000
ICC: 1:50-1:200
FC: 1:50-1:100
Western blot analysis of SCGB1A1 on mouse lung tissue (1) and A549 cell (2) lysate using anti-SCGB1A1 antibody at 1/500 dilution.
ICC staining SCGB1A1 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining SCGB1A1 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining SCGB1A1 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of A549 cells with SCGB1A1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
背景
SCGB1A1 also named CC10. Clara cell 10 (CC10) protein, a homologue of rabbit uteroglobin, is a phospholipase A2 inhibitor. CC10 is regulated by AP-1, octamer, and hepatocyte nuclear factor-3 (HNF-3) family transcription factors. CC10 expression changes in relation to the ovarian menstrual cycle, and expression in human endometrium may be stimulated by progesterone, suggesting that CC10 may regulate eicosanoid levels in the human uterus. CC10 is expressed in nonciliated airway epithelial cells in the lung and in urogenital secretions. CC10 is involved in modulating inflammation in airway passages and may play a role in asthma. Overexpression of CC10 in the non-small cell lung cancer cell line A549 was shown to result in the near absence of MMP-2 and MMP-9 matrix metalloproteinases and a reduction in invasiveness, indicating that loss of CC10 may contribute to carcinogenesis.
背景文献
1. Laukaitis CM et al. Evolution of the secretoglobins: a genomic and proteomic view. Biological Journal of the Linnean Society 84(3):493�C501 (2005).
2. Klug J et al. Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report. Ann N Y Acad Sci 923:348�C54 (2000).
Yes
