DNA Ligase I Rabbit mAb - SAB | Signalway Antibody

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DNA Ligase I Rabbit mAb#49797

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Recombinant

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产品详情

产品名称DNA Ligase I Rabbit mAb

来源种属Recombinant Rabbit

克隆性 Monoclonal antibody

克隆号JB43-39

纯化ProA affinity purified

应用WB,IHC

种属反应性Hu, Rt

别名DNA ligase 1 antibody
DNA ligase I antibody
DNLI1_HUMAN antibody
LIG 1 antibody
lig1 antibody
Ligase I DNA ATP dependent antibody
MGC117397 antibody
MGC130025 antibody
Polydeoxyribonucleotide synthase [ATP] 1 antibody

数据库入口号Swiss-Prot#:P18858

计算分子量Predicted band size 102 kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情

WB: 1:500
IHC: 1:50-1:200

Western blot analysis of DNA Ligase I on different cell lysates using anti-DNA Ligase I antibody at 1/500 dilution.
Positive control:
Lane 1: Daudi
Lane 2: A431
Lane 3: MCF-7

Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-DNA Ligase I antibody. Counter stained with hematoxylin.

Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-DNA Ligase I antibody. Counter stained with hematoxylin.

Immunohistochemical analysis of paraffin-embedded rat testis tissue using anti-DNA Ligase I antibody. Counter stained with hematoxylin.

背景

This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.

背景文献

1. Pascal J M et al. Human DNA ligase I completely encircles and partially unwinds nicked DNA. Nature 432:473-478 (2004).
2. Baple E L et al. Hypomorphic PCNA mutation underlies a human DNA repair disorder. J Clin Invest 124:3137-3146 (2014).

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操作手册

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应用

WB免疫印迹
IHC免疫组化
IF免疫荧光
ICC免疫细胞化学
FC流式细胞
IP免疫沉淀
E酶联免疫吸附法
DB免疫斑点法
ChIP染色质免疫沉淀
GICA胶体金免疫层析法
NC阴性对照

种属反应性

Hu人
Ms小鼠
Rt大鼠
Dm果蝇
C线虫
Mk猴
Rb兔
B牛
D狗
P猪
Hm仓鼠
ChHm中国仓鼠
Chk鸡

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DNA Ligase I Rabbit mAb#49797

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