产品详情
产品名称DDAH2 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号JB59-33
纯化ProA affinity purified
应用WB,IP
种属反应性Hu, Ms, Rt
免疫原描述Synthetic peptide within Human DDAH2 aa 1-100
别名DDAH antibody
DDAH II antibody
DDAH-2 antibody
DDAH2 antibody
DDAH2_HUMAN antibody
DDAHII antibody
Dimethylargininase 2 antibody
Dimethylargininase-2 antibody
Dimethylarginine dimethylaminohydrolase 2 antibody
Dimethylarginine dimethylaminohydrolase II antibody
G6a antibody
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 antibody
NG dimethylarginine dimethylamino hydrolase homolog antibody
NG30 antibody
OTTHUMP00000029307 antibody
OTTHUMP00000029310 antibody
OTTHUMP00000174488 antibody
OTTHUMP00000174489 antibody
Protein G6a antibody
S phase protein antibody
S-phase protein antibody
数据库入口号Swiss-Prot#:O95865
计算分子量30kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:2,000-1:5,000
IP: 1:10-:50
背景
DDAH, a dimethylarginine dimethylaminohydrolase, hydrolyzes dimethyl arginine (ADMA) and monomethyl arginine (MMA), both inhibitors of nitric oxide synthases, and may be involved in in-vivo modulation of nitric oxide production. Impairment of DDAH causes ADMA accumulation and a reduction in cGMP generation. DDAH II, the predominant DDAH isoform in endothelial cells, facilitates the induction of nitric oxide synthesis by all-trans-Retinoic acid (atRA). DDAH proteins are highly expressed in colon, kidney, stomach and liver tissues.
背景文献
1. Leiper J M et al. Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. Biochem J 343:209-214 (1999).
2. Cillero-Pastor B et al. Dimethylarginine dimethylaminohydrolase 2, a newly identified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes. Arthritis Rheum 64:204-212 (2012).
Yes
