产品详情
产品名称DEK Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号JB36-32
纯化ProA affinity purified
应用WB,IP
种属反应性Hu
免疫原描述Recombinant protein corresponding to C-terminal human DEK.
别名D6S231E antibody
Dek antibody
DEK gene antibody
DEK oncogene antibody
DEK oncogene DNA binding antibody
DEK_HUMAN antibody
Protein DEK antibody
数据库入口号Swiss-Prot#:P35659
计算分子量43 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:1,000
IP: 1:50-1:100
背景
The mammalian nuclear phosphoprotein DEK is implicated in multiple cellular processes, including transcriptional regulation, mRNA processing, and chromatin remodeling, and is associated with a number of clinical autoimmune and neoplastic conditions. DEK, an abundant chromatin-associated protein, changes the topology of DNA in chromatin in vitro. Although first identified in a fusion with the CAN/Nup214 nucleoporin protein in a specific subtype of acute myelogenous leukemia, DEK is also an autoantigen in patients with Pauciarticular onset juvenile rheumatoid arthritis. Furthermore, the last 65 amino acids of DEK can partially reverse the mutation-prone phenotype of cells from patients with ataxia-telangiectasia. The human DEK gene maps to chromosome 6p22.3.
背景文献
1. Hu H.G et al. The distribution of the DEK protein in mammalian chromatin. Biochem Biophys Res Commun 358:1008-1014 (2007).
2. Takata H et al. Proteome analysis of human nuclear insoluble fractions. Genes Cells 14:975-990 (2009).
Yes
