产品详情
产品名称EGR2 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆号JG78-39
纯化ProA affinity purified
应用WB,FC
种属反应性Hu, Ms, Rt
别名AT591 antibody
CMT1D antibody
CMT4E antibody
DKFZp686J1957 antibody
E3 SUMO-protein ligase EGR2 antibody
Early growth response 2 antibody
Early growth response protein 2 antibody
EGR-2 antibody
egr2 antibody
EGR2_HUMAN antibody
FLJ14547 antibody
KROX 20 Drosophila homolog antibody
Krox 20 homolog Drosophila antibody
KROX-20, Drosophila, homolog (early growth response-2) antibody
KROX20 antibody
Krox20 protein antibody
Zinc finger protein Krox-20 antibody
数据库入口号Swiss-Prot#:P11161
计算分子量50 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:1,000
FC: 1:50-1:100
背景
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene.
背景文献
1. Garcia-Gutierrez P. et al. The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators. EMBO Rep. 12:1018-1023(2011).
2. Funalot B. et al. Homozygous deletion of an EGR2 enhancer in congenital amyelinating neuropathy. Ann. Neurol. 71:719-723(2012).
Yes
