Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.

[1] Dahlstrand J., McKay R.D.G., Zimmerman L.B., Lendahl U.Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments.J. Cell Sci.1992.103;589-597.[2]Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,