产品详情
产品名称Cardiac Troponin I Monoclonal Antibody
来源种属Mouse
克隆性Monoclonal
纯化protein G purifed
应用WB
种属反应性Hu
特异性Reacts equally with free cardiac troponin I and cardiac troponin I forming complexes with other troponin components. Not affected by heparin, phosphorylation and oxidation. No cross-reactivity with skeletal muscle troponin I.
免疫原类型protein
免疫原描述Recombinant Human Cardiac Troponin I protein
基因/蛋白名称Cardiac Troponin I
别名CTnI
数据库入口号Swiss-Prot#: P19429
UniprotP19429
计算分子量23kd
浓度1.0mg/mL
配方Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
保存Store at -20˚C
应用详情
Western blotting: 1:500 - 1:1000
背景
Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium.
背景文献
[1] Apple FS.Tissue specificity of cardiac troponin I,cardiac troponin T and creatine Kinase-MB[J].Clin Chim Acta,1999,284:151-159 [2] Stein PD, Janjua M, Matta F, Pathak PK, Jaweesh F, Alrifai A, Chughtai HL. Prognosis based on creatine kinase isoenzyme
yes
