产品详情
产品名称ZNHIT1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用IHC WB
种属反应性Hu
特异性The antibody detects endogenous levels of total ZNHIT1 protein.
免疫原类型protein
免疫原描述Full length fusion protein
基因/蛋白名称ZNHIT1
别名CG1I; ZNFN4A1
数据库入口号Swiss-Prot#: O43257
NCBI Gene ID: 10467
UniprotO43257
计算分子量18kd
浓度1mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:200-1000
Immunohistochemistry: 1: 30-150
Gel: 12%SDS-PAGE
Lysate: 40 μg, Lane: 293T cell lysate ,
Primary antibody:ZNHIT1 antibody at dilution 1/400,
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,
Exposure time: 30 seconds
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ZNHIT1 Antibody at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using ZNHIT1 Antibody at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200)
背景
ZNHIT1 (zinc finger, HIT-type containing 1), also known as CG1I (cyclin-G1-binding protein 1), p18 hamlet or ZNFN4A1 (zinc finger protein subfamily 4A member 1), is a 154 amino acid protein that plays a role in the induction of p53-mediated apoptosis. A member of the ZNHIT1 family, ZNHIT1 contains one HIT-type zinc finger and interacts with p38. ZNHIT1 undergoes post-translational phosphorylation and is encoded by a gene that maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance.
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