产品详情
产品名称Arginase-1 Antibody
来源种属Mouse
克隆性Monoclonal
克隆号IHC400
应用IHC
种属反应性Human
配方Tris Buffer, pH 7.3 - 7.7, with 1%
BSA and <0.1% Sodium Azide
保存Store at 2-8C. Do not freeze.
应用详情
Recommended
working dilution range:1:100 - 1:200
产品描述
Arginase-1, encoded by the ARG1 gene, is a cytosolic metalloenzyme expressed predominantly in hepatocytes which plays a key role in the urea cycle by catalyzing the hydrolysis of arginine to ornithine and urea. Argininemia is an inherited autosomal recessive disorder characterized by a buildup of arginine and ammonia in the blood. Anti-Arginase-1 is highly specific for hepatocytes, and is therefore a sensitive and specific marker of benign and malignant hepatic tumors.
背景文献
Morris SM Jr. Br J Pharmacol. 2009; 157:922C930.
Uchino T, et al. Human Genetics. 2009; 96:255C60.
Yan BC, et al. Am J Surg Pathol. 2010; 34:1147-1154.
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