产品详情
产品名称BSEP Antibody
来源种属Mouse
克隆性Monoclonal
克隆号IHC518
应用IHC
种属反应性Human
配方Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
保存Store at 2-8C. Do not freeze.
应用详情
Recommended
working dilution range:1:100 - 1:200
产品描述
Bile Salt Export Pump (BSEP) is a member of the ATP-binding cassette (ABC) transporters, which mediates the transport of bile acid, taurocholate and other cholate conjugates across the hepatocyte canalicular membrane into the canaliculus. BSEP is associated with progressive familial intrahepatic cholestasis type 2 (PFIC2) and benign recurrent intrahepatic cholestasis type 2 (BRIC2). PFIC2 caused by mutations in the BSEP gene increases the risk of hepatocellular carcinoma in early life.
背景文献
Strautnieks S, et al. Nature Genetics. 1998; 20:233C8.
No J, et al. Gastroenterology. 2002; 123:1659C66.
Arrese M, et al. Pflgers Archiv. 2004; 449:123C31.
Jansen PL, et al. Gastroenterology. 1999; 117:1370C9.
van Mil SW, et al. Gastroenterology. 2004; 127:379C84.
Knisely AS, et al. Hepatology. 2006; 44:478C86.
in stock (1 week)
