p53, also known as tumor protein 53 or TP53, is a tumor suppressor and transcription factor that functions in a number of anti-cancer activities including DNA repair, cell-cycle arrest, and apoptosis in response to DNA damage or other stressors. Mutations in p53 are linked to a number of malignant tumors, including those of the breast, ovarian, bladder, colon, lung, and melanoma. Anti-p53 staining has been used to detect intratubular germ cell neoplasia, and also to distinguish between uterine serous carcinoma and endometrioid carcinoma.
Stoehlmacker J, et al. Oncol. 2003; 30:10-16. Gallo O, et al. Hum Pathol. 2002; 33:708-714. Sano H, et al. Cancer Res. 1995: 55:3785-9. Denkert C, et al. Cancer. 2003; 97:2978-87. Sheehan KM, et al. Hum Pathol. 2003; 34:1242-1246. Moore BE, et al. Appl Immunohistochem Mol Morphol. 2001; 9:203-6. Mauri FA, et al. Int J Oncol. 1999; 15:1137-47. Caffo O, et al. Clin Cancer Res. 1996; 2:1591-9. Bebenek M, et al. Anticancer Res. 1998; 18:619-23. Midulla C, et al. Anticancer Res. 1999; 19:4033-7. Zen ZS, et al. J Clin Oncol. 1994; 12:2043-50. Quinlan DC, et al. Cancer Res. 1992; 53:4828-31. Alexiev BA, et al. Gen Diagn Pathol. 1997; 142:271-9.
in stock (1 week)
